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Exosomes in Relapsing-Remitting Multiple Sclerosis Have Distinct RNA Profile

July 31, 2017

According to a study published in the Annals of Neurology, circulating exosomes have a distinct RNA profile in relapsing-remitting multiple sclerosis (RRMS). Igor Selmaj, MD, and a research team from the Medical University of Lodz in Poland, used next generation sequencing to define the global RNA profile of serum exosomes. The study consisted of 19 RRMS patients and 10 healthy controls (HCs). They analyzed 5,000,000 reads and over 50,000 transcripts, including detailed analysis of microRNA (miRNA) differentially expressed in RRMS.

The discovery data set was validated using data from an independent cohort of 63 RRMS patients (33 in relapse and 30 in remission) and 32 HCs. The researchers found that in RRMS patients vs HCs, 15 different classes of transcripts detected 4 circulating exosomal sequences within the miRNA category that were differentially expressed. During relapse there was a significant decrease of serum exosomal expression of these miRNA in RRMS. Since putative targets for these miRNA include the signal transducer and activator of transcription 3 and the cell cycle regulator aryl hydrocarbon receptor the data suggest a disturbed cell-to-cell communication in this disease," the authors write.

Via Neurology Advisor