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In Relapsing MS, Fatigue, Limb Problems May Signal Risk for Disease Conversion

April 24, 2017

Patients with relapsing-remitting multiple sclerosis (RRMS) who experience fatigue and lower limb problems may be running the risk of conversion to secondary progressive MS (SPMS).

The results were from the study presented at the 2017 annual meeting of the American Academy of Neurology, held from April 22-28, in Boston, Massachusetts. In the study, Caila Vaughn, PhD, MPH, of the New York State Multiple Sclerosis Consortium and the State University of New York at Buffalo, and colleagues chose to explore patient-reported outcomes that might be predictive of conversion from RRMs to SPMS.

The study included 155 patients with RRMS with a disease duration of at least 15 years. Analyses to evaluate he predictive value of patient-reported outcomes were performed at study enrollment and 5-year follow-up. The results overall, depicted that fatigue and lower limb problems were strongly correlated with conversions to SPMS even after adjusting for age and disease duration.

Given the results, the investigators suggested that identifying these patients prior to conversion would allow for health care providers to target them with tailored therapeutic strategies.

 Via Neurology Advisor