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Sodium Intake and Its Association with Multiple Sclerosis Progression

June 14, 2017

A study published in the Annals of Neurology found that there is no association between average 24-hour urine sodium levels and conversion from clinically isolated syndrome (CIS) to clinically definite multiple sclerosis (MS). The study was performed by Kathryn C. Fitzgerald, ScD, from the Johns Hopkins School of Medicine in Baltimore, and colleagues. They examined whether a high-salt diet is associated with faster conversion from CIS to MIS. The study included a total of 465 patients with CIS.

The patients provided a median of 14 spot urine samples during a 5-year follow-up of the BENEFIT trial. The researchers observed no correlation between the urine sodium levels and conversion to clinically define MS over the 5-year follow-up. There were also no associations with clinically or magnetic resonance imaging (MRI) outcomes, relative change in T2 lesion volume, change in Expanded Disability Status Scale, and relapse rate. In categorical analyses using quintiles, the results were similar. The study’s results show that salt intake does not influence MS disease course or activity.

Via Neurology Advisor