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Stem Cells from Gum Tissue Stopping MS Progression

January 13, 2016

A study that was published in the Stem Cell Research & Therapy journal indicated that stem cells isolated from the human periodontal ligament (HPDL), better known as the gum, could offer a potential treatment capable of halting MS progression.

These cells are called mesenchymal stem cells (MSCs) and are known to separate into several different types of central nervous system (CNS) cells. These CNS cells have the ability to modulate the immune system and enhance the remyelination and repairing process.

The research team set out to investigate the therapeutic potential for MS of an alternative source of stem cell that are less invasive for removal. The mice were induced and after two weeks they were administered an IV injection of the HPDLs cells.

Researchers observed diminished clinical signs, and decreased lymphocytic infiltration and demyelination in the spinal cord and brain tissues. Administration of the HPL cells also exerted a modulatory effect on the expression of several inflammatory cells and inflammation key markers.

In conclusion, the results suggest that transplantation of HPDL’s may become a new therapeutic strategy for halting MS progression.