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Pomegranate Seed Oil May Inhibit Progress in MS

November 30, 2015

In a recent study, researchers show how a natural antioxidant within pomegranate seeds is capable of inhibiting demyelination in a mouse model for multiple sclerosis (MS), supporting novel formulations of natural antioxidants as therapeutics for demyelinating diseases.

The study began when researchers administered a nano-droplet formulation of pomegranate seed oil (PSO). A previous study done by the team has showed that Nano-PSO could reduce brain lipids oxidation in a mouse model.

PSO contains a strong natural antioxidant named “punicic acid”. Administering PSO as an oil-in-water nano-emulsion is believed to increase both its bioavailability and activity. The study results somewhat agreed, as the oil when delivered in a natural state, was effective in high-dosages.

The benefits were visible when Nano-PSO was given to mice at the time the disease was induced, and again when EAE mice start to develop disease symptoms (day 7). These results suggest that Nano-PSO has a therapeutic potential both for preventing the disease and for impairing its progression. These findings support the idea that natural antioxidants are beneficial to patients with MS.