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'Low T' and MS Risk in Men

July 3, 2018

Statistics show that men are three times less likely than women to develop multiple sclerosis. Research has shown that men also develop MS at a later age than women and that their disease is more progressive. Could this all be related to “low T,” or low testosterone?

Researchers at Boston’s Brigham and Women’s Hospital have been researching this possibility. It’s part of a larger group of studies named CLIMB (Comprehensive Longitudinal Investigation of Multiple Sclerosis). Some of the findings that relate to testosterone are described in a recent article in the e-letter of the Accelerated Cure Project for MS.

According to the e-letter, interim results have revealed that a lot of men with MS also have low testosterone levels. Other recent research has indicated that low “T” levels may be an MS risk factor.

If that’s so, could testosterone therapy help with MS symptoms? According to the article, maybe so. A small pilot study of male MS patients by the UCLA medical school demonstrated that testosterone therapy provided significant improvements in cognitive function and slowed brain tissue loss. The article cautions, however, that this study still needs to be validated by a study that’s both larger and placebo-controlled.